Human Phospho-Tau (Thr217) Monoclonal Antibody Pair & Calibrator

Capture mAb: RDM013 | Detection mAb: RDM012 | Calibrator: RDP001

Developed specifically for ultrasensitive blood-based Alzheimer’s disease diagnosis. Provides site-specific recognition of Tau phosphorylated at Threonine 217 with zero cross-reactivity toward unphosphorylated Tau, p-Tau181, or p-Tau231, delivering exceptional clinical correlation with amyloid and tau PET positivity.

Validated Platforms: CLIA (Chemiluminescence), ELISA, Lateral Flow, Simoa
Specificity: Strictly specific to human p-Tau217 (No unphosphorylated Tau cross-binding)
Purity: >95% determined by SDS-PAGE analysis
Host / Clonality: Mouse Monoclonal Antibody (In-House Production)
Supply Capability: Multi-gram industrial batch capacity / Lot-to-lot consistent

Request Evaluation Sample → Download CoA / Tech Dossier

Standard Matched Formulation & Ordering Information

Recommended matched antibody pairs and authentic calibrators for clinical sandwich assay development:

Component Type	Catalog No.	Target / Specificity	Host / Source	Formulation / Buffer
Capture Monoclonal Antibody	RDM013	Human Phospho-Tau (Thr217 specific)	Mouse mAb	PBS (pH 7.4), Preservative-free
Detection Monoclonal Antibody	RDM012	Human Tau (Continuous epitope)	Mouse mAb	PBS (pH 7.4), Conjugation-ready
Calibrator Standard	RDP001	Recombinant / Synthetic p-Tau217	Synthetic / In-vitro phosphorylated	Lyophilized / High Stability

Analytical Performance & Assay Development Highlights

Strict Epitope Selectivity

Engineered to discriminate Thr217 phosphorylation from adjacent phosphorylation sites (p-Tau181, p-Tau231), preventing cross-reactivity and false-positive readouts in clinical testing.

Sub-Picogram Plasma Detection

High functional affinity tailored for magnetic bead CLIA and digital single-molecule immunoassay systems to detect minute p-Tau217 elevations in early/preclinical AD blood samples.

Robust Matrix Compatibility

Demonstrates minimal endogenous heterophilic antibody interference and excellent spike-recovery across human EDTA plasma, serum, and cerebrospinal fluid (CSF) matrices.

Clinical Significance of p-Tau217 as a Gold-Standard AD Biomarker

Tau protein phosphorylation at threonine 217 (p-Tau217 / Phospho-Tau 217) has emerged globally as the most diagnostically accurate blood-based biomarker for Alzheimer’s disease (AD). Unlike conventional total-tau or historical phosphorylation sites, plasma p-Tau217 concentrations exhibit a profound dynamic change directly correlated with cerebral amyloid-beta plaque deposition and pathological tau tangle accumulation. Clinical trial cohorts and diagnostic guidelines have demonstrated that blood-based p-Tau217 diagnostic assays rival CSF biomarkers and amyloid-PET neuroimaging in sensitivity and area-under-the-curve (AUC > 0.95) precision. Measuring p-Tau217 enables ultra-early preclinical Alzheimer’s detection, differential diagnosis against non-AD neurodegenerative tauopathies, and objective patient monitoring during anti-amyloid therapy regimens.

Assay Platform Compatibility & Industrial Supply Standards

Phospho-Epitope Specificity Monoclonal capture clone precisely binds the phosphorylated Thr217 peptide epitope with zero cross-reactivity toward unphosphorylated Tau or p-Tau181/p-Tau231.

Sub-pg/mL Plasma Sensitivity Engineered with exceptional femtomolar affinity to achieve sub-picogram analytical sensitivity in direct serum and EDTA-plasma on CLIA, Simoa, and TRFIC platforms.

Multi-Gram Industrial Supply Produced in automated in-house bioreactors to ensure multi-gram batch consistency and security of supply for large-scale commercial IVD kit production.

Lot Release QC (CV < 5%) Every batch is certified by SDS-PAGE purity (>95%), RP-HPLC analysis, and functional pairing calibration curves against international reference standards.

Request Validation Samples or Inquire for Bulk Industrial Supply

Sample evaluation packs (50 µg – 1 mg) are available for verified IVD assay developers. Batch-specific Certificates of Analysis (CoA) are included with each shipment.

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