Human Neurofilament Light Chain (NFL) Matched Antibody Pair & Calibrator

Capture mAb: RDM014 | Detection mAb: RDM015 | Calibrator: RDP005

A universal biomarker for neuro-axonal damage across Alzheimer’s Disease (AD), Amyotrophic Lateral Sclerosis (ALS), and Multiple Sclerosis (MS). High affinity and minimal matrix interference enable low pg/mL-level analytical sensitivity in blood (plasma/serum) and CSF.

Validated Platforms: CLIA (Magnetic Microparticle), ELISA, Lateral Flow, Simoa
Specificity: Human NFL specific (No cross-reactivity with alpha-internexin)
Purity: >95% determined by SDS-PAGE analysis
Host / Clonality: Mouse Monoclonal Antibody (In-House Production)
Supply Capability: Multi-gram industrial batch capacity with lot-to-lot consistency

Request Evaluation Sample → Download CoA / Tech Dossier

Standard Matched Formulation & Ordering Information

Recommended matched antibody pairs and authentic calibrators for clinical sandwich assay development:

Component Type	Catalog No.	Target / Specificity	Host / Source	Formulation / Buffer
Capture Monoclonal Antibody	RDM014	Human NFL (Alpha-internexin free)	Mouse mAb	PBS (pH 7.4), Preservative-free
Detection Monoclonal Antibody	RDM015	Human NFL (Conjugation-ready)	Mouse mAb	PBS (pH 7.4), Preservative-free
Recombinant Calibrator Protein	RDP005	Full-length Human NFL	E. coli Expression	Lyophilized powder

Analytical Performance & Assay Development Highlights

High Blood-to-CSF Correlation

Ensures a tight correlation between peripheral blood (serum/plasma) and CSF concentrations, facilitating non-invasive longitudinal disease monitoring.

Low Background Noise

Epitopes selected to minimize heterophilic antibody interference, maintaining wide analytical measurement ranges in multi-patient cohorts.

Pan-Neurodegenerative Utility

Robust analytical performance across multiple indications including AD, ALS, Multiple Sclerosis, and acute traumatic brain injury regimens.

Request Validation Samples or Inquire for Bulk Industrial Supply

Sample evaluation packs (50 µg – 1 mg) are available for verified IVD assay developers. Batch-specific Certificates of Analysis (CoA) are included with each shipment.

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