Human Aβ1-42 Monoclonal Antibody Pair & Calibrator Set

Capture mAb: RDM009 | Detection mAb: RDM011 | Calibrator: RDP004

Our human Abeta 1-42 antibody pair is engineered for high-affinity sandwich immunoassay development. Specifically recognizing the C-terminus of Amyloid beta 1-42 with zero cross-reactivity toward Aβ1-40, it delivers exceptional analytical recovery and sensitivity for blood-based and CSF Alzheimer’s disease diagnostic platforms.

Validated Platforms: CLIA (Chemiluminescence), ELISA, Lateral Flow, Simoa
Specificity: Specific to human Aβ1-42 (No cross-reactivity with Aβ1-40)
Purity: >95% determined by SDS-PAGE analysis
Host / Clonality: Mouse Monoclonal Antibody (In-House Production)
Supply Capability: Multi-gram industrial batch capacity / Lot-to-lot consistent

Request Evaluation Sample → Download CoA / Tech Dossier

Product Components & Matched Formulation

Recommended matched antibody pairs and authentic calibrators for clinical sandwich assay development:

Component Type	Catalog No.	Target / Epitope	Host / Source	Formulation / Buffer
Capture Antibody	RDM009	Human Aβ1-42 Specific	Mouse mAb	PBS (pH 7.4), Preservative-free
Detection Antibody	RDM011	Human Aβ1-42 Epitope	Mouse mAb	PBS (pH 7.4), Conjugation-ready
Calibrator Standard	RDP004	Recombinant Human Aβ1-42	E. coli / Synthetic	Lyophilized / High Stability
Companion Calibrator	RDP003	Recombinant Human Aβ1-40	E. coli Expression	For Aβ42/Aβ40 Ratio Assays

Analytical Performance & Assay Development Highlights

Strict C-Terminal Specificity

Differentiates the single two-amino-acid tail variance between Aβ42 and Aβ40, preventing overestimation in complex plasma and CSF matrices.

Sub-Picogram Sensitivity

Engineered for magnetic microparticle CLIA platforms and ultrasensitive single-molecule digital immunoassays down to low pg/mL physiological ranges.

Aβ42 / Aβ40 Dual-Assay Support

Provides matched Aβ1-40 reagent sets (RDM056 / RDM008 / RDP003) to enable accurate ratio calculation for amyloid-positive diagnosis.

Biomarker Utility & Clinical Relevance in Alzheimer’s Disease

Amyloid Beta 1-42 (Aβ1-42) is a 42-amino acid peptide derived from the sequential proteolytic cleavage of amyloid precursor protein (APP) by β-secretase (BACE1) and γ-secretase complexes. In Alzheimer’s disease (AD) neuropathology, soluble Aβ1-42 aggregates into toxic oligomers, protofibrils, and senile plaques. Clinical diagnostic utility relies heavily on measuring absolute Aβ1-42 concentrations and the critical Aβ1-42 / Aβ1-40 ratio in cerebrospinal fluid (CSF) and blood plasma. A decreased plasma ratio serves as a sensitive, early-stage hallmark biomarker for cerebral amyloid burden, enabling high-accuracy cohort stratification for commercial diagnostic assays and clinical trials.

Industrial Supply Specifications & Quality Release

Gram-Scale Bulk Capacity In-house bioreactor fermentation lines guarantee consistent multi-gram supply capacity for IVD kit manufacturing without lot-to-lot batch shifts.

Batch Consistency (CV < 5%) Every production lot undergoes rigorous analytical release testing via RP-HPLC, SDS-PAGE purity, and sandwich ELISA pairing tests.

Regulatory Documentation Delivered with comprehensive lot-specific Certificate of Analysis (CoA), pairing validation curve reports, and cross-reactivity dossiers.

OEM Custom Conjugation Available in carrier-free format, glycerol-stabilized formulations, or pre-conjugated with Biotin, HRP, or Acridinium ester upon request.

Request Validation Samples or Inquire for Bulk Industrial Supply

Sample packs (50 µg – 1 mg) are available for verified assay developers. Lot-specific Certificates of Analysis (CoA) will be provided alongside delivery.

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